Formulated with the natural power of plant-based purified extracts, ESMEXIL may help support mental performance and cognitive processes.
ESMEXIL is not a medicine.
It is a nanotechnological plant-based dietary supplement.
Helps support the preservation of brain functions and memory.
Helps support feeling refreshed and energetic throughout the day.
Helps support students and professionals in maintaining focus on their tasks, even under intense workloads.
Let your memories stay alive.
What is Alzheimer?
Alzheimer is a condition that gradually progresses in the areas of the brain responsible for memory and learning. Scientific studies show that a peptide called amyloid-beta, which is naturally produced by the body, begins to accumulate excessively in the brain over the years, and this buildup makes communication between brain cells increasingly difficult. As a result, memory and cognitive abilities slowly decline, eventually leading to loss of awareness.
What are
we doing?
AYE Exocure scientists have taken this entire process into account and developed the AYE Exocure Advanced Manufacturing Technology, which led to the production of ESMEXIL. This technology transforms plant extracts—originally 1500–2000 nanometers in size—into nanoparticles smaller than 200 nanometers through special purification and refinement steps.
While extracts measuring 1500–2000 nanometers cannot cross the blood–brain barrier, nanoparticles reduced to below 200 nanometers can easily pass through. This allows the scientifically known beneficial components of Coffee, Ginseng, and Ginkgo biloba — the three plants that form ESMEXIL — to be delivered to the brain much more effectively.
In this way, ESMEXIL helps support protection against the accumulation of amyloid-beta peptides in the brain.
According to six-month toxicity studies conducted under FDA (U.S. Food and Drug Administration) and EMA (European Medicines Agency) standards, no side effects have been observed.
ESMEXIL is not a medicinal product. It is a plant-based dietary supplement.
Botanical Trio
Botanical Trio
The following information on Coffea arabica, Ginkgo biloba, and Panax ginseng is based on scientific findings in the respective fields, with corresponding references. Click “More Info” to view detailed studies and related publications.
Coffea Arabica
More than just a source of caffeine, Coffea arabica extract contains polyphenols, chlorogenic acids, and other bioactive compounds.
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May help support focus and alertness.¹
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May contribute to maintaining attention over time.²
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May help support daily mental performance.³
ESMEXIL, a plant-based dietary supplement developed with AYE Exocure Advanced Manufacturing Technology, contains purified Coffea arabica.
Ginkgo Biloba
A botanical with a heritage spanning thousands of years, Ginkgo biloba is renowned in traditional wellness practices.
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May help support healthy circulation and oxygen delivery to cells.⁴
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May help support the cellular defense mechanisms against oxidative stress.⁵
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May help support mental clarity and focus.⁶
ESMEXIL, a plant-based dietary supplement developed with AYE Exocure Advanced Manufacturing Technology, contains purified Ginkgo biloba.
Panax Ginseng
Celebrated in Eastern traditions as a powerful adaptogen, Panax ginseng is valued for its ability to help the body adapt to everyday challenges.
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May help support mental performance.⁷
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May help reduce fatigue.⁸
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May help promote resilience to stress and a sense of mental endurance.⁹
ESMEXIL, a plant-based dietary supplement developed with AYE Exocure Advanced Manufacturing Technology, contains purified Panax ginseng extract.
Why these three?
The nanotechnologic plant-based dietary supplement ESMEXIL formulation combines these three botanicals not only for their individual qualities but also for their complementary potential when brought together.
Each works in different yet harmonizing ways – and with NanoExtract Technology, their supportive properties are delivered in a highly refined, stable form.
Unique
Purified extracts of Coffea Arabica, Panax Ginseng and Ginkgo Biloba – three plants with a centuries-old tradition of promoting mental clarity.
Innovative
Formulated with the world's first NanoExtract technology: for particularly small particle sizes and maximum bioavailability.
Supportive
Specifically developed to support cognitive processes, mental performance and mental endurance in everyday life.
Naturally
100% plant-based, vegan and free from artificial additives – for a safe and natural application.
Scientifically based
The formulation is based on the latest findings from research and the development of innovative NanoTechnology.
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*Landucci, E., Pellegrini-Giampietro, D. E., Bilia, A. R., & Bergonzi, M. C. (2019).
Enhanced Neuroprotective Effects of Panax ginseng G115® and Ginkgo biloba GK501® Combinations in In Vitro Models of Excitotoxicity. International Journal of Molecular Sciences, 20(23), 5872. https://doi.org/10.3390/ijms20235872
*Kantarcıoğlu, M., Yıldırım, G., Akpınar Oktar, P., Yanbakan, S., Özer, Z. B., Sarıca, D. Y., Taşdelen, S., Bayrak, E., Akın Balı, D. F., Öztürk, S., Akçalı, K. C., Ezer, Ü., & Kürekçi, A. E. (2023). Coffee-derived exosome-like nanoparticles: Are they the secret heroes? Turkish Journal of Gastroenterology, 34(2), 161–169. https://doi.org/10.5152/tjg.2022.21895
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McLellan, T. M., Caldwell, J. A., & Lieberman, H. R. (2016). A review of caffeine’s effects on cognitive, physical and occupational performance. Neuroscience & Biobehavioral Reviews, 71, 294–312. https://doi.org/10.1016/j.neubiorev.2016.09.001
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Nehlig, A. (2010). Is caffeine a cognitive enhancer? Journal of Alzheimer’s Disease, 20(s1), S85–S94. https://doi.org/10.3233/JAD-2010-091315
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Haskell, C. F., Kennedy, D. O., Wesnes, K. A., & Scholey, A. B. (2005). Cognitive and mood improvements of caffeine in habitual consumers and habitual non-consumers of caffeine. Psychopharmacology, 179(4), 813–825. https://doi.org/10.1007/s00213-004-2104-3
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Maclennan, K. M., Darlington, C. L., & Smith, P. F. (2002). The CNS effects of Ginkgo biloba extracts and ginkgolide B. Progress in Neurobiology, 67(3), 235–257. https://doi.org/10.1016/S0301-0082(02)00016-3
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Smith, J. V., & Luo, Y. (2004). Studies on molecular mechanisms of Ginkgo biloba extract. Applied Microbiology and Biotechnology, 64, 465–472. https://doi.org/10.1007/s00253-003-1518-9
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Weinmann, S., Roll, S., Schwarzbach, C., Vauth, C., & Willich, S. N. (2010). Effects of Ginkgo biloba in dementia: systematic review and meta-analysis. BMC Geriatrics, 10, 14. https://doi.org/10.1186/1471-2318-10-14
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Kennedy, D. O., Scholey, A. B., & Wesnes, K. A. (2001). Differential, dose dependent changes in cognitive performance following acute administration of a Ginkgo biloba/Panax ginseng combination to healthy young volunteers. Nutritional Neuroscience, 4(5), 399–412. https://doi.org/10.1080/1028415X.2001.11747376
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Kim, H. G., Cho, J. H., Yoo, S. R., Lee, J. S., Han, J. M., Lee, N. H., Ahn, Y. C., Son, C. G. (2013). Antifatigue effects of Panax ginseng C.A. Meyer: a randomised, double-blind, placebo-controlled trial. Complementary Therapies in Medicine, 21(2), 113–121. https://pmc.ncbi.nlm.nih.gov/articles/PMC3659633/
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Choi, J., Kim, T. H., Choi, T. Y., Lee, M. S. (2013). Ginseng for health care: A systematic review of randomized clinical trials in humans. Journal of Ginseng Research, 37(4), 215–222. https://pmc.ncbi.nlm.nih.gov/articles/PMC3659633